This dissertation is a theoretical study of the relationship between digitality, knowledge, and power in the age of Big Data. My argument is that human medical research on psychedelic substances supports a critique of what I call "the data episteme." I use "episteme" in the sense developed by philosopher Michel Foucault, where the term describes an apparatus for determining the properties associated with the epistemic condition of scientificity. I write that the data episteme suppresses bodies of knowledge which do not bear the epistemic virtues associated with digital data. These include but are not limited to the capacities for positivistic representation and translation into discrete digital media. Drawing from scientific reports, I demonstrate that certain forms of knowledge regarding the therapeutic mechanisms of psychedelics cannot withstand positivistic representation and digitization. Henceforth, psychedelic research demands frameworks for epistemic legitimation which differ from those predicated on the criteria associated with the data episteme. I additionally claim that psychedelic inebriation promotes a form of thinking which has been called, by various theorists, "negative," "abstract," or "idiosyncratic" thought. Whereas the data episteme denies the existence of negative thought, psychedelic research suggests that this mental function is essential to the successful deposition of psychedelic substances as adjuncts to psychotherapy. For the reasons listed above, psychedelic science provides a uniquely salient lens on the normative operations of the data episteme.

In the course of suppressing non-digitizable knowledge, the data episteme implements what Foucault conceptualizes "knowledge-power," a term which affirms the fact that there is no meaningful difference between knowledge and power. Here, "power" may be defined as the power to promote but also to retract conditions on which phenomena may exist across all sites of social, intellectual, and political construction. I write that the data episteme seeks to both nullify the preconditions for negative thought and to naturalize the possibility of an infinite expansion of human mental activity, which in turn figures mentality as an inexhaustible resource for the commodity of digital data. The data episteme therefore reifies the logic of ceaseless economic proliferation, and as such, abets technologized capitalism. In the event that the data episteme fulfills its teleological goal to become total, virtually all that is thinkable would yield to economic subordination. I present psychedelic science as a site where knowledge which challenges the data episteme is empirically necessary, and which, by extension, attests to the existence of that which cannot be economically subsumed.