Počet záznamů: 1  

Ion transfer voltammetric and LC/MS investigations of the oxidative degradation process of fentanyl and some of its structural analogs

  1. 1.
    0566842 - ÚFCH JH 2024 RIV GB eng J - Článek v odborném periodiku
    Langmaier, Jan - Skopalová, J. - Zajacová Cechová, M. - Kahánková, T. - Jerga, R. - Barták, P. - Samec, Zdeněk - Navrátil, Tomáš
    Ion transfer voltammetric and LC/MS investigations of the oxidative degradation process of fentanyl and some of its structural analogs.
    Electrochimica acta. Roč. 441, FEB 2023 (2023), č. článku 141848. ISSN 0013-4686. E-ISSN 1873-3859
    Grant CEP: GA ČR(CZ) GA20-07350S
    Institucionální podpora: RVO:61388955
    Klíčová slova: Fentanyl * HO• radicals * Catalytic degradation * Ion transfer voltammetry
    Obor OECD: Physical chemistry
    Impakt faktor: 6.6, rok: 2022
    Způsob publikování: Omezený přístup

    Ion transfer voltammetry at a polarized ionic liquid membrane and LC/MS technique were used to investigate the oxidative time-resolved degradation of the frequently (mis)used opioid fentanyl and some of its structural analogs.
    The degradation is based on the reaction of opioids with hydroxyl radicals produced by the catalytic decomposition of hydrogen peroxide. Using the voltammetric technique, it was confirmed that the presence of Fe2+ions and hydrogen peroxide is essential in the degradation process of fentanyl(s). An increasing concentration of ferrous ions accelerates the described reactions, while the reaction rate is much less affected by the concentration of fentanyl.
    In an excess of ferrous ions, the course of the reaction can be approximated by a pseudo-first-order reaction with a half-time of 3.85 min. The generation of HO• radicals was proved to be the rate-determining step. Oxidative degradation processes of all investigated fentanyl-related drugs exhibit similar kinetics. A wide variety of fentanyl degradation products were detected and characterized using LC/MS analysis. Mono-, di- and trihydroxylated derivatives in several isomeric forms were observed most abundantly in a relatively short reaction time (5–30 min). The formation of norfentanyl has also been demonstrated.
    Trvalý link: https://hdl.handle.net/11104/0338116

     
    Název souboruStaženoVelikostKomentářVerzePřístup
    0566842.pdf01.3 MBVydavatelský postprintvyžádat
     
Počet záznamů: 1  

  Tyto stránky využívají soubory cookies, které usnadňují jejich prohlížení. Další informace o tom jak používáme cookies.