Počet záznamů: 1  

Thermoresponsive triblock copolymers as widely applicable 19F magnetic resonance imaging tracers

  1. 1.
    0565996 - ÚMCH 2023 RIV US eng J - Článek v odborném periodiku
    Kolouchová, K. - Groborz, Ondřej - Šlouf, Miroslav - Herynek, V. - Parmentier, L. - Babuka, David - Černochová, Zulfiya - Koucký, F. - Sedláček, O. - Hrubý, Martin - Hoogenboom, R. - van Vlierberghe, S.
    Thermoresponsive triblock copolymers as widely applicable 19F magnetic resonance imaging tracers.
    Chemistry of Materials. Roč. 34, č. 24 (2022), s. 10902-10916. ISSN 0897-4756. E-ISSN 1520-5002
    Grant CEP: GA TA ČR(CZ) TO01000074
    Výzkumná infrastruktura: Czech-BioImaging II - 90129
    Institucionální podpora: RVO:61389013
    Klíčová slova: physically crosslinked hydrogels * BAB block copolymers * fluorine-19 magnetic resonance imaging
    Obor OECD: Polymer science
    Impakt faktor: 8.6, rok: 2022
    Způsob publikování: Omezený přístup
    https://pubs.acs.org/doi/10.1021/acs.chemmater.2c02589

    Fluorine-19 magnetic resonance imaging (19F MRI) has emerged as a promising noninvasive diagnostic tool, broadening the diagnostic possibilities of commonly used proton MRI. Despite the potential of 19F MRI, an ideal tracer paving the way toward the entry of this method into common medical practice is yet to be developed. In this study, we report on a series of polymeric systems based on thermoresponsive poly[N-(2,2-difluoroethyl)acrylamide] (PDFEA), a polymer considered to be an ideal tracer for 19F MRI. The described systems are designed as BAB triblock copolymers, where B corresponds to thermoresponsive PDFEA blocks and A is a hydrophilic poly(ethylene glycol) block. These BAB triblock copolymers are able to form nanoparticles in dilute aqueous solutions, which undergo a transition into physically cross-linked hydrogels upon increasing the polymer concentration. Since thermoresponsive particle- and hydrogel-based systems are applicable in a wide range of biomedical applications, we created a diagnostic system with potential therapeutic properties (theranostic) as a widely tunable platform through straightforward synthesis while serving a multitude of applications. We analyzed the effect of the BAB block ratio on the self-assembly, thermoresponsiveness, and mechanical properties of the studied hydrogels, together with their suitability for 19F MRI. Finally, their biocompatibility was assessed on a relevant cell line.
    Trvalý link: https://hdl.handle.net/11104/0338351

     
     
Počet záznamů: 1  

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