Sending the message: specialized RNA export mechanisms in trypanosomes

0562964 - BC 2023 RIV GB eng J - Článek v odborném periodiku
Obado, S. - Rout, M.P. - Field, Mark Christian
Sending the message: specialized RNA export mechanisms in trypanosomes.
Trends in Parasitology. Roč. 38, č. 10 (2022), s. 854-867. ISSN 1471-4922. E-ISSN 1471-5007
GRANT EU: Wellcome Trust(GB) 204697/Z/16/Z
Institucionální podpora: RVO:60077344
Klíčová slova: eukaryotic * cells * mRNA
Obor OECD: Cell biology
Impakt faktor: 9.6, rok: 2022
Způsob publikování: Open access
https://www.sciencedirect.com/science/article/pii/S147149222200160X?via%3Dihub

Export of RNA from the nucleus is essential for all eukaryotic cells and has emerged as a major step in the control of gene expression. mRNA molecules are required to complete a complex series of processing events and pass a quality control system to protect the cytoplasm from the translation of aberrant proteins. Many of these events are highly conserved across eukaryotes, reflecting their ancient origin, but significant deviation from a canonical pathway as described from animals and fungi has emerged in the trypanosomatids. With significant implications for the mechanisms that control gene expression and hence differentiation, responses to altered environments and fitness as a parasite, these deviations may also reveal additional, previously unsuspected, mRNA export pathways.
Trvalý link: https://hdl.handle.net/11104/0340168