ANALYSIS OF HEMATOLOGICAL PARAMETERS IN RHEUMATOID ARTHRITIS PATIENTS RECEIVING BIOLOGICAL THERAPY: CONTRIBUTION TO PREVENTION OF AVOIDABLE HEMATOLOGICAL COMPLICATIONS

0556113 - BFÚ 2023 RIV DE eng J - Článek v odborném periodiku
Perečková, Jana - Martiniakova, S. - Payer, J. - Falk, Martin - Killinger, Z. - Perečko, Tomáš
ANALYSIS OF HEMATOLOGICAL PARAMETERS IN RHEUMATOID ARTHRITIS PATIENTS RECEIVING BIOLOGICAL THERAPY: CONTRIBUTION TO PREVENTION OF AVOIDABLE HEMATOLOGICAL COMPLICATIONS.
EXCLI Journal. Roč. 21, č. 2022 (2022), s. 580-594. ISSN 1611-2156. E-ISSN 1611-2156
Grant CEP: GA ČR(CZ) GJ17-08066Y; GA MŠMT(CZ) LTAUSA17160
Institucionální podpora: RVO:68081707
Klíčová slova: tumor-necrosis-factor * factor inhibitors * disease-activity * tnf-alpha * tocilizumab * neutrophil
Obor OECD: Cardiac and Cardiovascular systems
Impakt faktor: 4.6, rok: 2022
Způsob publikování: Omezený přístup
https://www.excli.de/index.php/excli/article/view/4702

Administration of biological therapy (BT) in rheumatoid arthritis (RA) patients is often associated with hemato-logical complications, which result in switching among therapies. Thus, there is an instant need for suitable screening parameters that will help to individualize the therapy and minimize the onset of adverse effects. We analyzed the hematological profile of 99 RA patients receiving TNF-alpha (Adalimumab ADA, Golimumab GOL, Etanercept ETA) or IL-6 receptor (Tocilizumab TCZ) inhibitors in order to find possible indicators to improve personalization of RA therapy. BTs significantly affect the levels of observed hematological parameters. In contrast to TNF-alpha inhibitors, TCZ normalized almost all monitored hematological parameters to values of healthy donors. Only GOL from the TNF-alpha inhibitors studied, was able to normalize neutrophil counts, as well as platelet indicators. Importantly, effects on the blood parameters (e.g. lymphocytes or platelet count) differ even within the same therapeutic group (anti-TNF alpha). Variable effects of individual biological agents in RA treatment point to importance to evaluate the patient's hematological profile to improve the selection of suitable BT. It will help to personalize the administration of BT and prevent unnecessary switching from an effective therapy just because of provocation of avoidable hematological complications.
Trvalý link: https://hdl.handle.net/11104/0340257