Synthesis and anti-fouling properties of zwitterionic poly(L-glutamic acid)

0573142 - ÚMCH 2024 RIV KR eng J - Článek v odborném periodiku
Hladysh, Sviatoslav - Dvořáková, Jana - Proks, Vladimír
Synthesis and anti-fouling properties of zwitterionic poly(L-glutamic acid).
Macromolecular Research. Roč. 31, č. 6 (2023), s. 593-601. ISSN 1598-5032. E-ISSN 2092-7673
Grant CEP: GA ČR(CZ) GA21-06524S
Institucionální podpora: RVO:61389013
Klíčová slova: zwitterionic polymer * poly(L-glutamic acid) * anti-fouling
Obor OECD: Polymer science
Impakt faktor: 2.4, rok: 2022
Způsob publikování: Omezený přístup
https://link.springer.com/article/10.1007/s13233-023-00145-6

Zwitterionic polymers are frequently used as non-fouling materials for surface modification with following application in medical devices, implants or areas of our lives such as food, water, and energy. Here, authors report the synthesis of zwitterionic poly(l-glutamic acid) copolymer bearing sulfobetaine via combining the ring-opening polymerization of N-carboxyanhydride of γ-benzyl-l-glutamate and grafting reaction of propargylamine, tyramine, and 3-(dimethylamino)-1-propylamine to the polymer backbone with subsequent reaction of 1,3-propanesultone leading to the formation of zwitterionic poly(l-glutamic acid) containing sulfobetaine groups. Zwitterionic properties of the copolymer are represented by positively charged quaternary ammonium groups and negatively charged sulfobetaine moieties. The chemical structure of the synthesized zwitterionic poly(l-glutamic acid) was characterized by 1H NMR, FTIR, and UV/Vis spectroscopy. The zwitterionic abilities of copolymer were confirmed by zeta potential measurements. The zeta potential of zwitterionic polymer decreased from + 15 mV to − 19 mV upon stepwise pH increases from 2 to 11. The surface properties such as hydrophilicity and non-fouling abilities were tested by contact angle analysis and surface plasmon resonance technique, respectively. The prepared material indicates the formation of highly hydrophilic surfaces with relatively low contact angle (26°) and remarkable anti-protein adsorption functions reflected in lower resonance wavelength shifts from SPR sensogram. Results of this work show the importance of the developed biodegradable zwitterionic poly(l-glutamic acid)-based coatings for applications in various biomedical fields.
Trvalý link: https://hdl.handle.net/11104/0345105