Thioether-based poly(2-oxazoline)s: from optimized synthesis to advanced ROS-responsive nanomaterials

0577520 - ÚMCH 2024 RIV GB eng J - Článek v odborném periodiku
Bener, S. - Pavlova, Ewa - Beneš, Hynek - Sedláček, O.
Thioether-based poly(2-oxazoline)s: from optimized synthesis to advanced ROS-responsive nanomaterials.
Polymer Chemistry. Roč. 14, č. 42 (2023), s. 4838-4847. ISSN 1759-9954. E-ISSN 1759-9962
Institucionální podpora: RVO:61389013
Klíčová slova: ring-opening polymerization * drug-delivery * block-copolymers
Obor OECD: Polymer science
Impakt faktor: 4.6, rok: 2022
Způsob publikování: Open access
https://pubs.rsc.org/en/content/articlelanding/2023/PY/D3PY00945A

Intelligent redox-responsive polymers, such as thioether-containing macromolecules, facilitate drug delivery and triggered release in biomedical applications. Moreover, reactive oxygen species (ROS)-responsive thioether systems based on poly(2-oxazoline)s (PAOx) platforms hold great promise for the development of highly biocompatible, stimuli-responsive biomaterials. However, thioether-containing PAOx are particularly difficult to synthesize because thioethers are incompatible with the cationic ring-opening polymerization (CROP). In this study, we aim at developing an alternative route to well-defined thioether-containing PAOx by a simple post-polymerization modification of linear polyethyleneimine. First, the synthesis of ROS-responsive PAOx homopolymers was optimized. Furthermore, ROS-sensitive amphiphilic diblock copolymers poly(ethylene glycol)-block-poly(2-methylthiomethyl-2-oxazoline) were synthesized by combining CROP with 2-oxazoline side-chain interchange via a polyethyleneimine block intermediate. In an aqueous environment, the copolymers self-assembled into thioether-containing micelles. These micelles were characterized by size exclusion chromatography, nuclear magnetic resonance, matrix-assisted laser desorption/ionization-time of flight mass spectrometry, dynamic light scattering, differential scanning calorimetry, and transmission electron microscopy. In addition, treatment with diluted H2O2 destabilized the nanoparticles, thus demonstrating their oxidation-responsiveness. This approach provides key insights into the design and development of stimuli-responsive polymers for potential biomedical applications, such as drug delivery systems.
Trvalý link: https://hdl.handle.net/11104/0346667