Retinal venular vessel diameters are smaller during ten days of bed rest

0581564 - ÚŽFG 2024 RIV US eng J - Článek v odborném periodiku
Saloň, I. - Ciftci, G. M. - Zubac, D. - Šimunič, B. - Pišot, R. - Narici, M. - Fredriksen, P. M. - Nkeh-Chungag, B. N. - Sourij, H. - Šerý, Omar - Schmid-Zalaudek, K. - Steuber, B. - De Boever, P. - Goswami, N.
Retinal venular vessel diameters are smaller during ten days of bed rest.
Scientific Reports. Roč. 13, č. 1 (2023), č. článku 19258. ISSN 2045-2322. E-ISSN 2045-2322
Institucionální podpora: RVO:67985904
Klíčová slova: baroreflex control * plasma-volume * blood-flow * risk * microgravity * hypertension * responses * atrophy
Obor OECD: Cardiac and Cardiovascular systems
Impakt faktor: 4.6, rok: 2022
Způsob publikování: Open access
https://www.nature.com/articles/s41598-023-46177-x

Older individuals experience cardiovascular dysfunction during extended bedridden hospital or care home stays. Bed rest is also used as a model to simulate accelerated vascular deconditioning occurring during spaceflight. This study investigates changes in retinal microcirculation during a ten-day bed rest protocol. Ten healthy young males (22.9 +/- 4.7 years, body mass index: 23.6 +/- 2.5 kg center dot m-2) participated in a strictly controlled repeated-measures bed rest study lasting ten days. High-resolution images were obtained using a hand-held fundus camera at baseline, daily during the 10 days of bed rest, and 1 day after re-ambulation. Retinal vessel analysis was performed using a semi-automated software system to obtain metrics for retinal arteriolar and venular diameters, central retinal artery equivalent and central retinal vein equivalent, respectively. Data analysis employed a mixed linear model. At the end of the bed rest period, a significant decrease in retinal venular diameter was observed, indicated by a significantly lower central retinal vein equivalent (from 226.1 mu m, CI 8.90, to 211.4 mu m, CI 8.28, p = .026), while no significant changes in central retinal artery equivalent were noted. Prolonged bed rest confinement resulted in a significant (up to 6.5%) reduction in retinal venular diameter. These findings suggest that the changes in retinal venular diameter during bedrest may be attributed to plasma volume losses and reflect overall (cardio)-vascular deconditioning.
Trvalý link: https://hdl.handle.net/11104/0349760