Deciphering the early innate immune response to bordetella pertussis infection

0581908 - MBÚ 2024 RIV CZ eng A - Abstrakt
Brázdilová, Ludmila - Holubová, Jana - Staněk, Ondřej - Bumba, Ladislav - Niederlová, Veronika - Neuwirth, Aleš - Michálik, Juraj - Štěpánek, Ondřej - Šebo, Peter
Deciphering the early innate immune response to bordetella pertussis infection.
Czech Chem. Soc. Symp. Series. Roč. 21, č. 5 (2023), s. 209-209
[Annual meeting of the National Institute of Virology and Bacteriology (NIVB) /2./. 02.10.2023-05.10.2023, Kutná Hora]
Grant CEP: GA MŠMT(CZ) LX22NPO5103
Institucionální podpora: RVO:61388971 ; RVO:68378050
Klíčová slova: Bordetella pertussis * immune response * qPCR analysis * nasal mucosa
Obor OECD: Microbiology; Immunology (UMG-J)

Bordetella pertussis, a strictly human pathogen, elicits a highly contagious respiratory disease known as pertussis, or whooping cough. Current mouse models enabled identification of many bacterial virulence factors and development of pertussis vaccines, but mechanisms underlying the process of B. pertussis transmission during the catarrhal phase of pertussis disease remain largely unexplored due to lack of a convenient animal model. Recently, we have used immunodeficient MyD88 knock-out mice to achieve a human-like high level of nasal mucosa infection that triggers rhinitis and catarrhal shedding of bacteria from mouse nasal cavity, yielding transmission of the infection onto co-housed adult animals.
Trvalý link: https://hdl.handle.net/11104/0350055