- Author
-
Y.C.L. Haan
- Title
- Cardiovascular risk in women with uterine fibroids of different ethnic groups
- Supervisors
-
S. Middeldorp
- Co-supervisors
-
L.M. Brewster
- Award date
- 13 February 2020
- Number of pages
- 149
- ISBN
- 9789463757546
- Document type
- PhD thesis
- Faculty
- Faculty of Medicine (AMC-UvA)
- Abstract
-
In young women admissions for myocardial infarction are rising and mortality rates are still higher than in men. Just as worryingly, ethnic disparities still exist with a higher mortality due to heart disease in young African compared to Caucasian women. In this thesis, we investigated a new female-specific cardiovascular risk factor: uterine fibroids. We showed that women with uterine fibroids have a worse cardiovascular risk compared to controls, with more hypertension and a higher cardiovascular disease burden. The association between hypertension and fibroids was confirmed in multi-ethnic samples of the Netherlands, Suriname and the U.S. Moreover, although African women already have the highest prevalence of hypertension and hypertension-related cardiovascular morbidity and mortality, this is further increased in the presence of uterine fibroids.
We postulated in this thesis that the association between fibroids and hypertension is due to common growth factors and vaso-active peptides, stimulating vascular contractility and smooth muscle proliferation.
This thesis illustrates that clinicians should be aware of the increased hypertension and cardiovascular risk of women with fibroids, in particular in African women, and be assertive in screening for hypertension and target organ damage. - Persistent Identifier
- https://hdl.handle.net/11245.1/952bfa56-3384-43b8-a74a-95b43173d155
- Downloads
-
Thesis (complete)
Front matter
Chapter 1: Introduction and outline of the thesis
Chapter 2: Hypertension risk in Dutch women with symptomatic uterine fibroids
Chapter 3: The risk of hypertension and cardiovascular disease in women with uterine fibroids
Chapter 4: Cardiovascular disease in women with uterine fibroids: Data from NHANES
Chapter 5: Increased arterial stiffness in women with uterine fibroids
Chapter 6: Creatine kinase as a marker of obesity in a multi-ethnic population
Chapter 7: Summary and perspectives
Nederlandse samenvatting; List of publications; Authors and affiliations; Portfolio; Dankwoord; About the author
Stellingen
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