- Author
-
E. Boon
M.H. Valstar
W.T.A. van der Graaf
E. Bloemena
S.M. Willems
C.A. Meeuwis
P.J. Slootweg
L.A. Smit
M.A.W. Merkx
R.P. Takes
J.H.A.M. Kaanders
P.J.T.A. Groenen
U.E. Flucke
C.M.L. van Herpen - Date
- 7-2018
- Title
- Clinicopathological characteristics and outcome of 31 patients with ETV6-NTRK3 fusion gene confirmed (mammary analogue) secretory carcinoma of salivary glands
- Journal
- Oral Oncology
- Volume
- 82
- Pages (from-to)
- 29-33
- Document type
- Article
- Faculty
- Faculty of Dentistry (ACTA)
- Abstract
-
Objectives: In 2010, a new subtype of salivary gland cancer (SGC), (mammary analogue) secretory carcinoma (SC), was defined, characterized by the ETV6-NTRK3 fusion gene. As clinical behavior and outcome data of this histological subtype tumor are still sparse, we aimed to describe the clinicopathological course and outcome of a series of translocation positive SC patients.
Patient and methods: We re-evaluated the pathological diagnosis of a subset of SGCs, diagnosed in 4 of 8 Dutch head and neck centers. Subsequently, tumors with a morphological resemblance to SC were tested for the ETV6-NTRK3 fusion gene using RT-PCR. Furthermore, patients prospectively diagnosed with SC were included. The clinical characteristics and outcomes were retrieved from the patient files.
Results: Thirty-one patients with ETV6-NTRK3 fusion gene positive SC were included. The median age was 49 years, 17 patients (55%) were male. Eighteen tumors (58%) arose in the parotid gland. One patient presented with lymph node metastasis. All patients underwent tumor resection and 4 patients had a neck dissection. Four patients had re-resection and 15 patients (48%) received postoperative radiotherapy. One patient developed a local recurrence, no regional recurrences or distant metastases were observed. After a median follow-up of 49 months the 5- and 10-year overall survival were 95%, the 5- and 10-year disease free survival were 89%.
Conclusion: The clinical course of SC is favorable with a low rate of locoregional recurrence and excellent survival. Given the low incidence of nodal metastases, elective neck treatment, i.e. surgery and/or radiotherapy, does not seem to be indicated. - URL
- go to publisher's site
- Other links
- Link to publication in Scopus
- Language
- English
- Persistent Identifier
- https://hdl.handle.net/11245.1/a5c7f15c-7efb-4ba8-8f9c-cc34e596d7a1
- Downloads
-
Clinicopathological characteristics and outcome of 31 patients with ETV6-NTRK3(Final published version)
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