Title
Exceptionally Elastic Single-Component Pharmaceutical Crystals
Abstract
We report here the first elastically bendable single-component pharmaceutical crystal, celecoxib. Interlocked molecular packing without the slip plane and the presence of an isotropic hydrogen bond network are major structural features responsible for both the exceptional elastic flexibility and high stiffness of the celecoxib crystal as revealed by bending and nanomechanical studies. The molecular model of the exceptional elasticity is rationalized by the inhomogeneous spatial separations of molecules in the bent crystal, which is further confirmed by micro-Raman spectroscopy. The celecoxib crystal, exhibiting both therapeutic effects and elastic mechanical behavior, could be used to manufacture functional microdevices with novel medical applications.
Identifiers
doi: 10.1021/acs.chemmater.9b00040
Suggested Citation
Sun, Changquan C.; Wang, Kunlin; Mishra, Manish.
(2019).
Exceptionally Elastic Single-Component Pharmaceutical Crystals.
ACS.
Retrieved from the University of Minnesota Digital Conservancy,
https://hdl.handle.net/11299/202377.