Artículo
Retinoprotective Effect of Wild Olive (Acebuche) Oil-Enriched Diet against Ocular Oxidative Stress Induced by Arterial Hypertension
Autor/es | Santana Garrido, Álvaro
Reyes Goya, Claudia Pérez-Camino, María del Carmen André, Helder Mate Barrero, Alfonso Vázquez Cueto, Carmen María |
Departamento | Universidad de Sevilla. Departamento de Fisiología |
Fecha de publicación | 2020 |
Fecha de depósito | 2020-12-03 |
Publicado en |
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Resumen | Oxidative stress plays an important role in the pathogenesis of ocular diseases,
including hypertensive eye diseases. The beneficial effects of olive oil on cardiovascular diseases
might rely on minor constituents. ... Oxidative stress plays an important role in the pathogenesis of ocular diseases, including hypertensive eye diseases. The beneficial effects of olive oil on cardiovascular diseases might rely on minor constituents. Currently, very little is known about the chemical composition and/or therapeutic effects of the cultivated olive tree’s counterpart, wild olive (also known in Spain as acebuche—ACE). Here, we aimed to analyze the antioxidant and retinoprotective effects of ACE oil on the eye of hypertensive mice made hypertensive via administration of NG-nitro-L-arginine-methyl-ester (L-NAME), which were subjected to a dietary supplementation with either ACE oil or extra virgin olive oil (EVOO) for comparison purposes. Deep analyses of major and minor compounds present in both oils was accompanied by blood pressure monitoring, morphometric analyses, as well as different determinations of oxidative stress-related parameters in retinal layers. Aside from its antihypertensive effect, an ACE oil-enriched diet reduced NADPH (nicotinamide adenine dinucleotide phosphate) oxidase activity/gene/protein expression (with a major implication of NADPH oxidase (NOX)2 isoform) in the retinas of hypertensive mice. Supplementation with ACE oil in hypertensive animals also improved alterations in nitric oxide bioavailability and in antioxidant enzyme profile. Interestingly, our findings show that the use of ACE oil resulted in better outcomes, compared with reference EVOO, against hypertension-related oxidative retinal damage. |
Agencias financiadoras | Ministerio de Ciencia e Innovación (MICIN). España Consejería de Economía, conocimiento, Empresas y Universidad, Junta de Andalucía |
Identificador del proyecto | 2017/440
2020/275 CTS-584 PID2019-109002RB-I00 |
Cita | Santana Garrido, Á., Reyes Goya, C., Pérez-Camino, M.d.C., André, H., Mate Barrero, A. y Vázquez Cueto, C.M. (2020). Retinoprotective Effect of Wild Olive (Acebuche) Oil-Enriched Diet against Ocular Oxidative Stress Induced by Arterial Hypertension. Antioxidants, 9, 1-32. |
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Retinoprotective Effect.pdf | 6.142Mb | [PDF] | Ver/ | |