Artículo
Biomarkers predictive value for early diagnosis of Stroke- Associated Pneumonia.
Autor/es | Zapata Arriaza, Elena
Mancha Molina, Fernando Moniche Álvarez, Francisco Pardo Galiana, Blanca Vega Salvatierra, Ángela Ramos Herrero, Víctor Darío Montaner, Joan |
Departamento | Universidad de Sevilla. Instituto de Biomedicina de Sevilla. Grupo Neurovascular. |
Fecha de publicación | 2019-06-25 |
Fecha de depósito | 2020-03-26 |
Publicado en |
|
Resumen | To confirm the diagnostic accuracy of candidate biomarkers in stroke-associ-
ated pneumonia (SAP), we prospectively enrolled ischemic stroke patients with
NIHSS ≥ 10 on admission from March-2016 to August-2017. Blood ... To confirm the diagnostic accuracy of candidate biomarkers in stroke-associ- ated pneumonia (SAP), we prospectively enrolled ischemic stroke patients with NIHSS ≥ 10 on admission from March-2016 to August-2017. Blood samples were collected at baseline, 24 and 48 h after stroke onset. Biomarkers (MR- proADM, suPAR, SAA) were determined by immunoassays. Regarding biomarkers, MR-proADM at 24 h (P = 0.04) and both suPAR and SAA at 48 h (P = 0.036 and P = 0.057) were associated with pneumonia. The combination of SAA > 25.15 mg/dL and suPAR> 3.14 ng/mL at 48 h had 80% sensitivity and 95.8% specificity when both biomarkers were above the cut-off. The evalu- ated biomarkers represent promising tools to be evaluated in future large, prospective studies on SAP. An accurate SAP diagnosis by thorax CT might help to reduce variability in such studies. |
Agencias financiadoras | ISCIII project ITRIBiS project (Improving Translational Research Potential at the Institute of Biomedicine of Seville) Instituto de Salud Carlos III |
Identificador del proyecto | PI14/00971
REGPOT-2013-1 JR16/0008 |
Cita | Zapata Arriaza, E., Mancha Molina, F., Moniche Álvarez, F., Pardo Galiana, B., Vega Salvatierra, Á., Ramos Herrero, V.D. y Montaner, J. (2019). Biomarkers predictive value for early diagnosis of Stroke- Associated Pneumonia.. Annals of clinical and translational neurology., 6 (9), 1882-1887. |
Ficheros | Tamaño | Formato | Ver | Descripción |
---|---|---|---|---|
Biomarkers predictive value.pdf | 307.9Kb | [PDF] | Ver/ | |