Cognitive function in association with high estradiol levels resulting from fertility treatment

Leeners, Brigitte; Krüger, Tillmann; Geraedts, Kirsten; Tronci, Enrico; Mancini, Toni; Ille, Fabian; Egli, Marcel; Röblitz, Susanna; Wunder, Dorothea; Saleh, Lanja; Schippert, Cordula; Hengartner, Michael Pascal

doi:10.1016/j.yhbeh.2021.104951

Publication type:	Article in scientific journal
Type of review:	Peer review (publication)
Title:	Cognitive function in association with high estradiol levels resulting from fertility treatment
Authors:	Leeners, Brigitte Krüger, Tillmann Geraedts, Kirsten Tronci, Enrico Mancini, Toni Ille, Fabian Egli, Marcel Röblitz, Susanna Wunder, Dorothea Saleh, Lanja Schippert, Cordula Hengartner, Michael Pascal
et. al:	No
DOI:	10.1016/j.yhbeh.2021.104951
Published in:	Hormones and Behavior
Volume(Issue):	130
Issue Date:	2021
Publisher / Ed. Institution:	Elsevier
ISSN:	0018-506X 1095-6867
Language:	English
Subjects:	Attention; Cognition; Cognitive bias; Estradiol; Estrogen; Fertility treatment
Subject (DDC):	150: Psychology 610: Medicine and health
Abstract:	The putative association between hormones and cognitive performance is controversial. While there is evidence that estradiol plays a neuroprotective role, hormone treatment has not been shown to improve cognitive performance. Current research is flawed by the evaluation of combined hormonal effects throughout the menstrual cycle or in the menopausal transition. The stimulation phase of a fertility treatment offers a unique model to study the effect of estradiol on cognitive function. This quasi-experimental observational study is based on data from 44 women receiving IVF in Zurich, Switzerland. We assessed visuospatial working memory, attention, cognitive bias, and hormone levels at the beginning and at the end of the stimulation phase of ovarian superstimulation as part of a fertility treatment. In addition to inter-individual differences, we examined intra-individual change over time (within-subject effects). The substantial increases in estradiol levels resulting from fertility treatment did not relate to any considerable change in cognitive functioning. As the tests applied represent a broad variety of cognitive functions on different levels of complexity and with various brain regions involved, we can conclude that estradiol does not show a significant short-term effect on cognitive function.
URI:	https://digitalcollection.zhaw.ch/handle/11475/21831
Fulltext version:	Published version
License (according to publishing contract):	Licence according to publishing contract
Departement:	Applied Psychology
Organisational Unit:	Psychological Institute (PI)
Appears in collections:	Publikationen Angewandte Psychologie

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Leeners, B., Krüger, T., Geraedts, K., Tronci, E., Mancini, T., Ille, F., Egli, M., Röblitz, S., Wunder, D., Saleh, L., Schippert, C., & Hengartner, M. P. (2021). Cognitive function in association with high estradiol levels resulting from fertility treatment. Hormones and Behavior, 130. https://doi.org/10.1016/j.yhbeh.2021.104951

Leeners, B. et al. (2021) ‘Cognitive function in association with high estradiol levels resulting from fertility treatment’, Hormones and Behavior, 130. Available at: https://doi.org/10.1016/j.yhbeh.2021.104951.

B. Leeners et al., “Cognitive function in association with high estradiol levels resulting from fertility treatment,” Hormones and Behavior, vol. 130, 2021, doi: 10.1016/j.yhbeh.2021.104951.

LEENERS, Brigitte, Tillmann KRÜGER, Kirsten GERAEDTS, Enrico TRONCI, Toni MANCINI, Fabian ILLE, Marcel EGLI, Susanna RÖBLITZ, Dorothea WUNDER, Lanja SALEH, Cordula SCHIPPERT und Michael Pascal HENGARTNER, 2021. Cognitive function in association with high estradiol levels resulting from fertility treatment. Hormones and Behavior. 2021. Bd. 130. DOI 10.1016/j.yhbeh.2021.104951

Leeners, Brigitte, Tillmann Krüger, Kirsten Geraedts, Enrico Tronci, Toni Mancini, Fabian Ille, Marcel Egli, et al. 2021. “Cognitive Function in Association with High Estradiol Levels Resulting from Fertility Treatment.” Hormones and Behavior 130. https://doi.org/10.1016/j.yhbeh.2021.104951.

Leeners, Brigitte, et al. “Cognitive Function in Association with High Estradiol Levels Resulting from Fertility Treatment.” Hormones and Behavior, vol. 130, 2021, https://doi.org/10.1016/j.yhbeh.2021.104951.