Characterization and prediction of protein interfaces to infer protein-protein interaction networks

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2008-04-01

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Keskin, Ozlem
Tunçbağ, Nurcan
GÜRSOY, Attila

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Complex protein-protein interaction networks govern biological processes in cells. Protein interfaces are the sites where proteins physically interact. Identification and characterization of protein interfaces will lead to understanding how proteins interact with each other and how they are involved in protein-protein interaction networks. What makes a given interface bind to different proteins; how similar/different the interactions in proteins are some key questions to be answered. Enormous amount of protein structures and experimental protein-protein interactions data necessitate advanced computational methods for analyzing and inferring new knowledge. Interface prediction methods use a wide range of sequence, structural and physico-chemical characteristics that distinguish interface residues from non-interface surface residues. Here, we present a review focusing on the characteristics of interfaces and the current status of interface prediction methods.

Subject Keywords

Structurally Conserved Residues, Hot-Spots , Interaction Sites , Binding-Sites , Statistical-Analysis , Recognition Sites , Saccharomyces-Cerevisiae , Systems Biology , Patch Analysis , In-Silico

URI

https://hdl.handle.net/11511/32640

Journal

CURRENT PHARMACEUTICAL BIOTECHNOLOGY

DOI

https://doi.org/10.2174/138920108783955191

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Graduate School of Informatics, Article

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Citation Formats

O. Keskin, N. Tunçbağ, and A. GÜRSOY, “Characterization and prediction of protein interfaces to infer protein-protein interaction networks,” CURRENT PHARMACEUTICAL BIOTECHNOLOGY, pp. 67–76, 2008, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/32640.