Chemoenzymatic functionalization of cyclic 1,2-diketones

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2006

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Biçer, Işıl

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Chiral hydroxylated cyclopentane derivatives are important structural units in many biologically active compounds and are also important synthons for the asymmetric synthesis of natural products. Synthesis of these types of compounds in optically pure form found increased interest in pharmaceutical chemistry. For this purpose 5-acetoxy-3-methyl-2-methoxy-2-cyclopentene-1-one and 5-acetoxy-3-ethyl-2-methoxy-2-cyclopentene-1-one were acetoxylated using manganese (III) acetate at a’ positions. Enzyme catalyzed enantioselective hydrolysis of hydrolyzed acetoxy derivatives gives the corresponding hydroxylated diketones in optically pure form.

Subject Keywords

Chemistry, Organic

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http://etd.lib.metu.edu.tr/upload/12607293/index.pdf
https://hdl.handle.net/11511/16405

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Graduate School of Natural and Applied Sciences, Thesis

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Citation Formats

I. Biçer, “Chemoenzymatic functionalization of cyclic 1,2-diketones,” M.S. - Master of Science, Middle East Technical University, 2006.