Influence of stimulatory and suppressive DNA motifs on host susceptibility to inflammatory arthritis.

Date

2003-06-01

Author

Zeuner, RA
Verthelyi, D
Gürsel, Mayda
Ishii, KJ
Klinman, DM

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Objective. To examine whether systemic administration of immunostimulatory and immunosuppressive oligodeoxynucleotides (ODNs) alter host susceptibility to inflammatory arthritis. Methods. Normal BALB/c mice were treated systemically with CpG ODNs or suppressive ODNs, and then challenged intraarticularly with CpG DNA. The onset and magnitude of the resulting inflammatory response was monitored. Results. Systemic delivery of CpG ODNs significantly increased susceptibility to local inflammation, whereas systemic treatment with suppressive ODNs reduced this susceptibility. CD11c+ cells played a key role in mediating host sensitivity to arthritis. These cells were the dominant source of tumor necrosis factor a production in CpG-stimulated animals and transferred resistance to arthritis from mice treated with suppressive ODNs. Conclusion. Systemic exposure to immunostimulatory and immunosuppressive DNA influences host susceptibility to local inflammatory challenge. Current findings raise the possibility that suppressive ODNs may be useful in the prevention/treatment of proinflammatory diseases.

Subject Keywords

Immunology, Immunology and Allergy, Pharmacology (medical), Rheumatology

URI

https://hdl.handle.net/11511/34725

Journal

Arthritis and rheumatism

DOI

https://doi.org/10.1002/art.11035

Collections

Department of Biology, Article

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Citation Formats

R. Zeuner, D. Verthelyi, M. Gürsel, K. Ishii, and D. Klinman, “Influence of stimulatory and suppressive DNA motifs on host susceptibility to inflammatory arthritis.,” Arthritis and rheumatism, pp. 1701–7, 2003, Accessed: 00, 2020. [Online]. Available: https://hdl.handle.net/11511/34725.