Investigation of interaction between DCDC2 and KIAA0319 in a large German 
dyslexia sample

Ludwig, K. U.; Roeske, D.; Schumacher, J.; Schulte-Körne, G.; König, I. R.; Warnke, A.; Plume, E.; Ziegler, A.; Remschmidt, H.; Müller-Myhsok, B.; Nöthen, M. M.; Hoffmann, P.

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Investigation of interaction between DCDC2 and KIAA0319 in a large German dyslexia sample

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Müller-Myhsok, B.
AG Müller-Myhsok, Bertram, Florian Holsboer (Direktor), Max Planck Institute of Psychiatry, Max Planck Society;

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引用

Ludwig, K. U., Roeske, D., Schumacher, J., Schulte-Körne, G., König, I. R., Warnke, A., Plume, E., Ziegler, A., Remschmidt, H., Müller-Myhsok, B., Nöthen, M. M., & Hoffmann, P. (2008). Investigation of interaction between DCDC2 and KIAA0319 in a large German dyslexia sample. Journal of Neural Transmission, 115(11), 1587-1589.

引用: https://hdl.handle.net/11858/00-001M-0000-000E-939F-B

要旨

The dyslexia susceptibility locus DYX2 (chr. 6p21-p22) harbours two candidate genes, DCDC2 and KIAA0319. In 2006, Harold et al. reported evidence for interaction between both genes. Having previously identified a risk haplotype for dyslexia in DCDC2, but not KIAA0319, in German families, we also tested for interaction between this risk haplotype and KIAA0319. We found a nominally significant association for the quantitative dimension "word reading", the core phenotype in the study of Harold et al., which may be considered as supportive evidence.