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Journal Article

Myelin water mapping by spatially regularized longitudinal relaxographic imaging at high magnetic fields

MPS-Authors
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Labadie,  Christian
Methods and Development Unit Nuclear Magnetic Resonance, MPI for Human Cognitive and Brain Sciences, Max Planck Society;
Laboratoire de Spectrométrie Ionique et Moléculaire, Université Claude Bernard, Lyon, France;
Faculty of Physics and Earth Sciences, University of Leipzig, Germany;

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Möller,  Harald E.
Methods and Development Unit Nuclear Magnetic Resonance, MPI for Human Cognitive and Brain Sciences, Max Planck Society;

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https://onlinelibrary.wiley.com/doi/10.1002/mrm.24670
(Publisher version)

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Citation

Labadie, C., Lee, J.-H., Rooney, W. D., Jarchow, S., Aubert-Frécon, M., Springer Jr., C. S., et al. (2014). Myelin water mapping by spatially regularized longitudinal relaxographic imaging at high magnetic fields. Magnetic Resonance in Medicine, 71(1), 375-387. doi:10.1002/mrm.24670.


Cite as: https://hdl.handle.net/11858/00-001M-0000-000E-E02A-E
Abstract
Purpose: Magnetic resonance T1-weighted images are routinely used for human brain segmentation, brain parcellation, and clinical diagnosis of demyelinating diseases. Myelin is thought to influence the longitudinal relaxation commonly described by a mono-exponential recovery, although reports of bi-exponential longitudinal relaxation have been published. The purpose of this work was to investigate if a myelin water T1 contribution could be separated in geometrically sampled Look-Locker trains of low flip angle gradient echoes. Methods: T1 relaxograms from normal human brain were computed by a spatially regularized inverse Laplace transform after estimating the apparent inversion efficiency. Results: With sufficiently long inversion-time sampling (ca. 5 × T1 of cerebrospinal fluid), the T1 relaxogram revealed a short-T1 peak (106–225 ms). The apparent fraction of this water component increased in human brain white matter from 8.3% at 3 T, to 11.3% at 4 T and 15.0% at 7 T. The T2* of the short-T1 peak at 3 T was shorter, 27.9 ± 13.0 ms, than that of the long-T1 peak, 51.3 ± 5.6 ms. Conclusion: The short-T1 fraction is interpreted as the water resident in myelin. Its detection is facilitated by longer T1 of axoplasmic water at higher magnetic field.