ECEPE proteins: a novel family of eukaryotic cysteine proteinases

Ginalsk, Krzysztof; Zemojtel, Tomasz

doi:10.1016/j.tibs.2004.08.003

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ECEPE proteins: a novel family of eukaryotic cysteine proteinases

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Zemojtel, Tomasz
Dept. of Computational Molecular Biology (Head: Martin Vingron), Max Planck Institute for Molecular Genetics, Max Planck Society;

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Ginalsk, K., & Zemojtel, T. (2004). ECEPE proteins: a novel family of eukaryotic cysteine proteinases. Trends in Biochemical Sciences: TIBS / International Union of Biochemistry and Molecular Biology, 29(10), 524-526. doi:10.1016/j.tibs.2004.08.003.

Cite as: https://hdl.handle.net/11858/00-001M-0000-0010-87CC-D

Abstract

Using a variety of fold-recognition methods, a novel eukaryotic cysteine proteinase (ECEPE) family has been identified. This family encompasses sequences from an uncharacterized KOG4621, including the Arabidopsis thaliana guanylyl cyclase-related protein AtGC1. ECEPE proteins are predicted to possess the papain-like cysteine proteinase fold and are evolutionarily linked to C39 peptidases. The presence of the invariant Cys-His-Asp/Asn catalytic triad and the oxyanion-hole glutamine residue characteristic of papain-like cysteine proteases indicate that ECEPE proteins might function as proteases.