Spatial Dependence of the Nonlinear BOLD Response at Short Stimulus Duration

Pfeuffer, J; McCullough JC, Van de Moortele P-F, Ugurbil, K; Hu, X

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Spatial Dependence of the Nonlinear BOLD Response at Short Stimulus Duration

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Pfeuffer, J
Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Citation

Pfeuffer, J., McCullough JC, Van de Moortele P-F, Ugurbil, K., & Hu, X. (2002). Spatial Dependence of the Nonlinear BOLD Response at Short Stimulus Duration. Poster presented at 10th Scientific Meeting of the International Society of Magnetic Resonance in Medicine (ISMRM 2002), Honolulu, HI, USA.

Cite as: https://hdl.handle.net/11858/00-001M-0000-0013-DFE4-E

Abstract

Non-linearities in the measured BOLD data were found for the response integral and width. With the high sensitivity at 7T, a voxel-based analysis was feasible and was used to investigate the spatial dependence of the non-linearities at high spatial resolution. Correlation between response onset and non-linearity suggests that the origin of the observations are a tissue-specific phenomenon. Comparison with 4T and 1.5T data also indicates a field dependence. The observed non-linearity at short stimulus duration (SD) has likely a considerable hemodynamic contribution and thus must be accounted for in event-related fMRI paradigms.