MS susceptibility is not affected by single nucleotide polymorphisms in the 
MMP9 gene

Nischwitz, S.; Wolf, C.; Andlauer, T.F.M.; Czamara, D.; Zettl, U. K.; Rieckmann, P.; Buck, D.; Ising, M.; Bettecken, T.; Mueller-Myhsok, B.; Weber, F.

doi:10.1016/j.jneuroim.2015.01.008

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MS susceptibility is not affected by single nucleotide polymorphisms in the MMP9 gene

MPS-Authors

/persons/resource/persons80459

Nischwitz, S.
Max Planck Institute of Psychiatry, Max Planck Society;

/persons/resource/persons80596

Wolf, C.
Max Planck Institute of Psychiatry, Max Planck Society;

/persons/resource/persons125664

Andlauer, T.F.M.
Max Planck Institute of Psychiatry, Max Planck Society;

/persons/resource/persons80291

Czamara, D.
Max Planck Institute of Psychiatry, Max Planck Society;

/persons/resource/persons80379

Ising, M.
Max Planck Institute of Psychiatry, Max Planck Society;

/persons/resource/persons80269

Bettecken, T.
Max Planck Institute of Psychiatry, Max Planck Society;

/persons/resource/persons80450

Mueller-Myhsok, B.
Max Planck Institute of Psychiatry, Max Planck Society;

/persons/resource/persons80578

Weber, F.
Max Planck Institute of Psychiatry, Max Planck Society;

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引用

Nischwitz, S., Wolf, C., Andlauer, T., Czamara, D., Zettl, U. K., Rieckmann, P., Buck, D., Ising, M., Bettecken, T., Mueller-Myhsok, B., & Weber, F. (2015). MS susceptibility is not affected by single nucleotide polymorphisms in the MMP9 gene. JOURNAL OF NEUROIMMUNOLOGY, 279, 46-49. doi:10.1016/j.jneuroim.2015.01.008.

引用: https://hdl.handle.net/11858/00-001M-0000-0028-F54F-D

要旨

Matrix metalloproteinase 9 (MMP9) plays an important role in the pathogenesis of multiple sclerosis (MS). However, the impact of genetic variants affecting MMP9 on MS susceptibility is still in debate. We could not detect an association of MMP9 SNPs with MS on a genome-wide significance level by SNP genotyping, followed by imputation of SNPs within a region stretching 2 Mbp up-and down-stream of MMP9. Rs6073751, located within WFDC2, was found associated with MS most strongly. Rs3918242, associated with MS according to previous reports, showed nominal significance only. Meta-analysis of our own and published data did not confirm this effect. (C) 2015 Elsevier B.V. All rights reserved.