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Journal Article

Molecular beacons: nucleic acid hybridization and emerging applications

MPS-Authors
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Antony,  T.
Department of Molecular Biology, MPI for biophysical chemistry, Max Planck Society;

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Subramaniam,  V.
Department of Molecular Biology, MPI for biophysical chemistry, Max Planck Society;

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600090.pdf
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Citation

Antony, T., & Subramaniam, V. (2001). Molecular beacons: nucleic acid hybridization and emerging applications. Journal of Biomolecular Structure and Dynamics, 19, 497-504.


Cite as: https://hdl.handle.net/11858/00-001M-0000-0012-F742-7
Abstract
Molecular beacons (MBs) are a novel class of nucleic acid probes that become fluorescent when bound to a complementary sequence. Because of this characteristic, coupled with the sequence specificity of nucleic acid hybridization and the sensitivity of fluorescence techniques, MBs are very useful probes for a variety of applications requiring the detection of DNA or RNA. We survey various applications of MBs, including the monitoring of DNA triplex formation, and describe recent developments in MB design that enhance their sensitivity.