Studying block in cloned N-methyl--aspartate (NMDA) receptors

Ruppersberg, J. Peter; Mosbacher, Johannes; Günther, Willy; Schöpfer, Ralf; Fakler, Bernd

doi:10.1016/0006-2952(93)90627-9

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Studying block in cloned N-methyl--aspartate (NMDA) receptors

MPS-Authors

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Ruppersberg, J. Peter
Department of Cell Physiology, Max Planck Institute for Medical Research, Max Planck Society;

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Mosbacher, Johannes
Department of Cell Physiology, Max Planck Institute for Medical Research, Max Planck Society;

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Günther, Willy
Department of Cell Physiology, Max Planck Institute for Medical Research, Max Planck Society;

/persons/resource/persons95283

Schöpfer, Ralf
Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Max Planck Society;

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Fakler, Bernd
Max Planck Institute for Medical Research, Max Planck Society;

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http://www.sciencedirect.com/science/article/pii/0006295293906279/pdf?md5=98405a3a0b44c417e533d00feb5d01a8&pid=1-s2.0-0006295293906279-main.pdf
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https://doi.org/10.1016/0006-2952(93)90627-9
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引用

Ruppersberg, J. P., Mosbacher, J., Günther, W., Schöpfer, R., & Fakler, B. (1993). Studying block in cloned N-methyl--aspartate (NMDA) receptors. Biochemical Pharmacology, 46(11), 1877-1885. doi:10.1016/0006-2952(93)90627-9.

引用: https://hdl.handle.net/11858/00-001M-0000-0019-A9EB-5

要旨

The biophysics of block of NMDA receptor channels has been investigated extensively during the past 8 years. In the last few years, cloned NMDA receptor channels have become available. Here we have discussed advantages and disadvantages of studying block phenomena in cloned NMDA receptors. Some recent work on the pore block of the cloned NMDA receptor channels was critically reviewed and extended by data about the calcium block. Novel effects of kainate on cloned NMDA receptors and of NMDA on cloned AMPA receptors were reported and discussed with respect to recent work concerning possible occurrence of NMDA-AMPA hybrid channels.