Differences in Ca2+ permeability of AMPA-type glutamate receptor channels in 
neocortical neurons caused by differential GluR-B subunit expression

Jonas, Peter; Racca, Claudia; Sakmann, Bert; Seeburg, Peter H.; Monyer, Hannah

doi:10.1016/0896-6273(94)90444-8

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Differences in Ca2+ permeability of AMPA-type glutamate receptor channels in neocortical neurons caused by differential GluR-B subunit expression

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Jonas, Peter
Department of Cell Physiology, Max Planck Institute for Medical Research, Max Planck Society;

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Sakmann, Bert
Department of Cell Physiology, Max Planck Institute for Medical Research, Max Planck Society;

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Monyer, Hannah
Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Max Planck Society;

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http://www.sciencedirect.com/science/article/pii/0896627394904448/pdf?md5=8a9b0072d497d53e0163d1f3d6db2f9b&pid=1-s2.0-0896627394904448-main.pdf
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Citation

Jonas, P., Racca, C., Sakmann, B., Seeburg, P. H., & Monyer, H. (1994). Differences in Ca2+ permeability of AMPA-type glutamate receptor channels in neocortical neurons caused by differential GluR-B subunit expression. Neuron, 12(6), 1281-1289. doi:10.1016/0896-6273(94)90444-8.

Cite as: https://hdl.handle.net/11858/00-001M-0000-0019-A90C-C

Abstract

Fast excitatory synaptic transmission in the CNS is mediated by AMPA-type glutamate receptor (GluR) channels. Heterologous expression suggested that the Ca2+ permeability of these receptors critically depends on the subunit composition. Using patch-clamp techniques in brain slices, we found that the Ca2+ permeability of native AMPA-type GluRs was markedly higher in nonpyramidal (PCa/PK approximately 0.63) than in pyramidal (PCa/PK approximately 0.05) neurons of rat neocortex. Analysis of mRNA in single cells indicated that the relative abundance of GluR-B-specific mRNA was significantly lower in nonpyramidal (GluR-B/GluR-non-B approximately 0.3) than in pyramidal (GluR-B/GluR-non-B approximately 3) cells. This suggests that differences in relative abundance of GluR-B-specific mRNA generate functional diversity of AMPA-type GluRs in neurons with respect to Ca2+ permeability.