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C.B.E.M. Reusken (Chantal), H. Mou (Huihui), G-J. Godeke (Gert-Jan), L. van der Hoek (Lia), B. Meyer (Bernhard), M.A. Müller (Marcel), B.L. Haagmans (Bart), R. de Sousa (Rita), N. Schuurman, U. Dittmer, et al. P.J.M. Rottier (Peter), A.D.M.E. Osterhaus (Albert), C. Drosten (Christian), B.J. Bosch (Berend Jan) and M.P.G. Koopmans D.V.M. (Marion)

2013-04-26

Specific serology for emerging human coronaviruses by protein microarray

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Publication

Eurosurveillance , Volume 18 - Issue 14 p. 2- 7

We present a serological assay for the specific detection of IgM and IgG antibodies against the emerging human coronavirus hCoV-EMC and the SARS-CoV based on protein microarray technology. The assay uses the S1 receptor-binding subunit of the spike protein of hCoV-EMC and SARS-CoV as antigens. The assay has been validated extensively using putative cross-reacting sera of patient cohorts exposed to the four common hCoVs and sera from convalescent patients infected with hCoV-EMC or SARS-CoV.

Additional Metadata
Persistent URL hdl.handle.net/1765/87235
Journal Eurosurveillance
Grant This work was funded by the European Commission 7th Framework Programme; grant id fp7/223498 - European management platform for emerging and re-emerging infectious disease entities (EMPERIE)
Organisation Department of Virology
Citation
Reusken, C., Mou, H., Godeke, G.-J., van der Hoek, L., Meyer, B., Müller, M., … Koopmans, M., D.V.M. (2013). Specific serology for emerging human coronaviruses by protein microarray. Eurosurveillance, 18(14), 2–7. Retrieved from http://hdl.handle.net/1765/87235
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