Orally Disintegrating Tablets: A Review
Issue Date:
13-Jul-2009
Publisher:
Pharmacotherapy Group, Faculty of Pharmacy, University of Benin, Benin City, Nigeria
Description:
Drug delivery systems are becoming increasingly sophisticated as
pharmaceutical scientists acquire a better understanding of the
physicochemical and biochemical parameters pertinent to their
performance. Over the past three decades, orally disintegrating tablets
(ODTs) have gained considerable attention as a preferred alternative to
conventional tablets and capsules due to better patient compliance.
ODTs are solid dosage forms containing medicinal substances which
disintegrate rapidly, usually in a matter of seconds, when placed on
the tongue. Products of ODT technologies entered the market in the
1980s, have grown steadily in demand, and their product pipelines are
rapidly expanding. New ODT technologies address many pharmaceutical and
patient needs, ranging from enhanced life-cycle management to
convenient dosing for paediatric, geriatric, and psychiatric patients
with dysphagia. This has encouraged both academia and industry to
generate new orally disintegrating formulations and technological
approaches in this field. The aim of this article is to review the
development of ODTs, challenges in formulation, new ODT technologies
and evaluation methodologies, suitability of drug candidates, and
future prospects.
Content Type:
Article
Items in TSpace are protected by copyright, with all rights reserved, unless otherwise indicated.
link to htmlmap