Effect of Fear Memory Recall on Interpretation Bias in Rodents
Advisor:
Josselyn, Sheena
Department:
Medical Science
Issue Date:
Nov-2014
Abstract (summary):
Emotions influence interpretation of information. This psychological phenomenon is called interpretation bias. Although rodent studies have established negative interpretation biases due to chronic stressors, the effect of fear memory recall on interpretation bias is still unclear. Therefore, the goal of this study was to investigate the effect of fear memory recall on interpretation bias. We trained mice in a novel visual-based touchscreen paradigm to associate presentation of a large square with a large reward, and small square with a small reward. We then acutely activated a fearful memory through presentation of a tone previously paired with a foot-shock. We tested the effect of acute fear memory recall on following interpretation bias through a paradigm where mice associate ambiguous sized squares with either expectation of a large or small reward. Recall of fear memory did not induce an interpretation bias, but reduced overall motivation and reduced speed to interpret ambiguous stimuli.
Permanent Link:
https://hdl.handle.net/1807/68039
Content Type:
Thesis
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