Title:

Tryptophan Requirements in School Age Children Determined by the Indicator Amino Acid Oxidation Method; Preliminary Results

Issue Date: Jun-2016
Abstract (summary): Background: The Indicator Amino Acid Oxidation (IAAO) technique has shown that amino acids requirements are underestimated. The current tryptophan requirements for healthy school age children are based on factorial method and have never been re-evaluated using IAAO. Objective: To determine tryptophan requirements in healthy school age children by measuring the oxidation of L-[1-13C]phenylalanine to 13CO2 in response to graded intakes of tryptophan. Design: Three healthy school age children participated in 14 study days. Each study day had a different tryptophan intake. Stable isotopes were used as tracer to determine the oxidation level. Breath and urine samples were taken to compare the oxidation level.. Conclusion: With our current data, we were not able to define tryptophan requirements in healthy school age children using the IAAO method. However, we observed a decrease in L-[1-13C]phenylalanine oxidation level in relation to increase intake of tryptophan.
Content Type: Thesis

Permanent link

https://hdl.handle.net/1807/72674

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