Title:

Modular Synthesis of Chiral beta-Aminophosphine P,N-Ligands and Their Applications in Asymmetric Catalysis

Author: Song, Yixiong
Advisor: Taylor, Mark S.
Department: Chemistry
Issue Date: Nov-2015
Abstract (summary): A series of chiral beta-aminophosphine ligands bearing different carbon backbones and electronically differentiated diarylphosphino groups were prepared using a modular approach. These P,N-ligands were found to induce a modest level of enantioselectivities in the Pd-catalyzed asymmetric decarboxylative allylation reaction. Thiourea-phosphine bifunctional catalysts derived from the chiral beta-aminophosphine building blocks were prepared and applied to the asymmetric Morita-Baylis-Hillman (MBH) reaction of methyl acrylate and 4-nitrobenzaldehyde. The electronically unmodified diarylphosphino-thiourea was found to be optimal for achieving high activity and enantioselectivity in this particular MBH reaction. We also reported the synthesis of a P-chiral C2-symmetric bisphosphine ligand. However, the utility of this Trost-type ligand remains to be explored in the future.
Content Type: Thesis

Permanent link

https://hdl.handle.net/1807/74468

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