Title:

Novel Bismuth-Cetyltrimethylammonium Bromide Photocatalytic Nanomaterial for Antibacterial Applications

Author: Li, Shermaine
Advisor: Goh, M. Cynthia
Department: Chemistry
Issue Date: Nov-2017
Abstract (summary): Hospital-acquired infections (HAIs) have become a global concern, especially with the spread of antibiotic-resistant bacteria which can survive on surfaces from days to months. In order to combat these infections, a superior, next-generation antimicrobial agent was generated since conventional agents offer no residual effect beyond its single-use. This novel composite material contained a bismuth-based photocatalyst, and cetyltrimethylammonium bromide (CTAB), a known antiseptic surfactant which does not require photoactivation, allowing antibacterial activity under both indoor fluorescent light and dark conditions. The as-prepared Bi-CTAB composites have a highly crystalline, layered sheet-like structure with the thickness of a single layer around 0.5 nm. The number of layers can be easily tuned from single layer to multiple layers by the control of the hydrolysis process. These ultra-thin Bi-CTAB composites exhibited superior antibacterial action in both light and dark conditions, tested in a modified broth microdilution assay against E. coli concentrations of 5 x 10^5 CFU/mL. In the presence of light, Bi-CTAB composites retained significant bactericidal effect after four cycles of bacterial inoculation, demonstrating an advantage over single-use conventional agents. We anticipate these assay results to be a starting point in translating the composite into clinical setting as a general disinfectant.
Content Type: Thesis

Permanent link

https://hdl.handle.net/1807/79097

Items in TSpace are protected by copyright, with all rights reserved, unless otherwise indicated.