Title:

Oxygenation during Exercise in Individuals with Interstitial Lung Disease

Issue Date: Jun-2019
Abstract (summary): Individuals with interstitial lung disease (ILD) commonly exhibit exertional hypoxemia. The overall objective of this thesis was to examine aspects of oxygenation during exercise in ILD. The first study (Chapter 2) examined constant load endurance exercise with systemic arterial oxygen saturation monitoring using pulse oximetry. This study found that in a cohort of 375 lung transplant candidates with advanced ILD, high exertional oxygen requirements were required and were increased over time to prevent hypoxemia during exercise. Higher levels of exertional oxygen use were associated with a lower exercise capacity and aerobic training intensity. The second study (Chapter 3) was a cross-over study designed to compare feasibility (participant tolerance and preference) and acute cardiorespiratory responses of a single bout of interval exercise with a bout of continuous exercise on a cycle ergometer in nine lung transplant candidates with ILD. Findings from this study revealed that interval exercise was well tolerated and preferred. Interval exercise resulted in a lower peak heart rate with trends towards less arterial oxygen desaturation, lower leg fatigue and less elevation in blood lactate compared to continuous exercise. The third study (Chapter 4) prospectively examined regional skeletal muscle oxygenation/ deoxygenation and muscle blood volume using near infrared spectroscopy during upper and lower limb incremental loading in three groups: thirteen lung transplant candidates with oxygen dependent severe ILD, ten individuals with non-oxygen dependent mild/moderate ILD and thirteen healthy persons. This study showed that muscle deoxygenation occurred at a lower level of total work in the two ILD groups. During lower limb loading regional blood volume was attenuated in severe ILD compared to healthy persons. Regional muscle deoxygenation was not associated with systemic arterial oxygen saturation. The findings from these three studies provide insight into oxygen delivery and utilization during exercise in ILD. Individuals with ILD, exertional hypoxemia and high supplemental oxygen use presented with reduced exercise capacity during aerobic and resistance exercise and impairments in systemic and regional muscle oxygenation. Optimal oxygen supplementation and alternative modes of aerobic training may improve peripheral muscle oxygen utilization and capacity, and should be further studied.
Content Type: Thesis

Permanent link

https://hdl.handle.net/1807/95935

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