Title:

Impaired Motor Cortical Facilitatory-inhibitory Circuit Interactions in Parkinson’s Disease

Advisor: Chen, Robert
Department: Medical Science
Issue Date: Nov-2019
Abstract (summary): Motor cortical (M1) inhibition and facilitation can be studied with short-interval intracortical inhibition (SICI) and short-interval intracortical facilitation (SICF). These circuits as well as the sensorimotor measure short latency afferent inhibition (SAI) are altered in Parkinson’s disease (PD). The purpose of this study was to examine the interactions between these circuits in PD. Fifteen PD patients were studied in ON and OFF medication states, and were compared to 16 age-matched controls. A triple-stimulus transcranial magnetic stimulation paradigm was used to elicit a circuit of interest in the presence of another circuit. SICI facilitated SICF in controls and PD ON, but not PD OFF. Therefore, the facilitatory effect of SICI on SICF is not present in PD OFF, but is restored with dopaminergic medication. SAI and SICI inhibited each other in all groups. These results suggest impaired interaction between M1 facilitatory and inhibitory circuits is a pathophysiological feature of PD.
Content Type: Thesis

Permanent link

https://hdl.handle.net/1807/98344

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