The Leucine Requirement of Older Adult Men Determined by Indicator Amino Acid Oxidation Method
Advisor:
Courtney-Martin, Glenda
Department:
Nutritional Sciences
Issue Date:
Nov-2019
Abstract (summary):
Leucine recommendations for older adults are based on young adult data. When compared to young adults, older adults require more dietary leucine to stimulate muscle protein synthesis, suggesting that age may affect the leucine requirement.
We aimed to determine the leucine requirement of men ≥ 60 years using the indicator amino acid oxidation method.
Seven men ≥ 60 years were each assigned to receive seven levels of leucine intake ranging from 20 – 120 mg . kg-1 . d-1, in random order. The rate of release of 13CO2 from the oxidation of L-[1-13C]phenylalanine was measured and breakpoint analysis was applied to determine the leucine requirement.
The mean leucine requirement for men ≥ 60 years was estimated to be 80 mg . kg-1 . d-1; double the current recommendations. Current leucine recommendations for older adults need to be revisited.
Permanent Link:
https://hdl.handle.net/1807/98387
Content Type:
Thesis
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