Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/31677
Título: | Antitumoral and antiangiogenic activity of Portuguese propolis in in vitro and in vivo models |
Autor(es): | Carvalho, Ricardo Silva Gonçalves, Vera Mónica Miranda Ferreira, Ana Margarida Cardoso, Susana M. Sobral, Abílio J. F. N. Aguiar, Cristina Baltazar, Fátima |
Palavras-chave: | Portuguese propolis Cancer Antitumoural activity Antiangiogenic activity Cancer metabolism |
Data: | 2014 |
Editora: | Elsevier |
Revista: | Journal of Functional Foods |
Resumo(s): | Propolis, a natural product, has important biological properties, however, studies with Portuguese propolis are scarce. Thus, we aimed to characterize the chemical composition and the antitumoural and antiangiogenic activities of a sample from Pereiro (Portugal). The chemical profile of our propolis sample (P10.EE) is similar to the poplar propolis type. P10.EE decreased cell viability of different tumour cells, being less cytotoxic against non-tumoural cells. P10.EE decreased MDA-MB-231 and DU145 cell proliferation and migration, with cell cycle changes and increased cell death. The increased glucose consumption and lactate production in MDA-MB-231 cells is explained by an increased expression of different metabolism-related proteins. P10.EE induced a decrease in HBMEC cells total biomass and proliferation and decreased vessel sprouting in the chicken chorioallantoic membrane. Additionally, P10.EE potentiates paclitaxel effect in MDA-MB-231 and DU145 cells. Concluding, P10.EE can be a good candidate for cancer drug development since it affects different characteristics that dictate tumorigenesis. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/31677 |
DOI: | 10.1016/j.jff.2014.09.009 |
ISSN: | 1756-4646 |
Versão da editora: | http://www.journals.elsevier.com/journal-of-functional-foods/ |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | ICVS - Artigos em revistas internacionais / Papers in international journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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silva-carvalho r_j funct foods 2014 ip.pdf | 1,76 MB | Adobe PDF | Ver/Abrir |