Utilize este identificador para referenciar este registo:
https://hdl.handle.net/1822/58059
Título: | The impact of IL-10 dynamic modulation on host immune response against visceral leishmaniasis |
Autor(es): | Mesquita, Inês Morais Ferreira, Carolina Barbosa, Ana Margarida Ferreira, Catarina Machado Moreira, Diana Carvalho, Agostinho Cunha, Cristina Rodrigues, Fernando Dinis-Oliveira, Ricardo Jorge Estaquier, Jérôme Castro, António G. Torrado, Egídio Silvestre, Ricardo Jorge Leal |
Palavras-chave: | Visceral leishmaniasis IL-10 Multifunctional CD4+ T cells IFN-γ IFN-gamma |
Data: | Dez-2018 |
Editora: | Elsevier |
Revista: | Cytokine |
Citação: | Mesquita, I., Ferreira, C., Barbosa, A. M., Ferreira, C. M., et. al. (2018). The impact of IL-10 dynamic modulation on host immune response against visceral leishmaniasis. Cytokine, 112, 16-20 |
Resumo(s): | Leishmaniasis is a vector-borne disease caused by protozoan parasites from the genus Leishmania. The most severe form of disease is visceral leishmaniasis (VL), which is fatal if left untreated. It has been demonstrated that interleukin (IL)-10, is associated with disease progression and susceptibility. In this work, we took advantage of a transgenic mouse model that expresses high levels of IL-10 upon zinc sulfate administration (pMT-10). We addressed the role of IL-10 during the initial stages of L. donovani infection by analyzing the parasite burden in the spleen and liver of the infected pMT-10 and WT mice as well as the histopathological alterations upon IL-10 induction. Furthermore, the profile of cytokines expressed by T cells was assessed. Our results demonstrate that an increase in IL-10 production has an impact early but not later after infection. This specific temporal role for IL-10-mediated susceptibility to VL is of interest. |
Tipo: | Artigo |
URI: | https://hdl.handle.net/1822/58059 |
DOI: | 10.1016/j.cyto.2018.07.001 |
ISSN: | 1043-4666 |
e-ISSN: | 1096-0023 |
Versão da editora: | https://www.sciencedirect.com/science/article/pii/S1043466618302874 |
Arbitragem científica: | yes |
Acesso: | Acesso aberto |
Aparece nas coleções: | ICVS - Artigos em revistas internacionais / Papers in international journals |
Ficheiros deste registo:
Ficheiro | Descrição | Tamanho | Formato | |
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The impact of IL-10 dynamic modulation on host immune response against visceral leishmaniasis.pdf | 942,37 kB | Adobe PDF | Ver/Abrir |