Title:
Neural interface systems for long-term behavioral experiments with small freely moving animals
Neural interface systems for long-term behavioral experiments with small freely moving animals
Author(s)
Jia, Yaoyao
Advisor(s)
Inan, Omer T.
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Abstract
The objective of my research is to advance the neural interface systems for long-term behavioral experiments with small freely moving animals. Several innovative system- and circuit-level techniques are proposed towards the development of wireless power transmission (WPT) systems, inductively-powered implantable neural recording and stimulation interface, wireless data acquisition system, and distributed architecture consisting of multiple tiny implants.
Implantable medical devices (IMDs), which establish a direct communication pathway with the target neurons, are the tools for applying neuromodulation, while sensing neural signals to provide feedback on the evoked neural activities. This technique is known as closed-loop neuromodulation. Head-mounted devices, furnished with both neural recording and electrical stimulation and/or optical stimulation, have been developed to offer unprecedented flexibility for end-users. In addition, tiny implant design, with miniaturized footprint and minimized power consumption, has been proposed, aiming to develop the architecture of distributed tiny implants. For untethered and battery-free operation of the IMDs, supporting systems have been developed. Two WPT systems are presented in particular: EnerCage-HC and dual-band EnerCage-HC to wirelessly power and control head-mounted devices and tiny implants, respectively. A data acquisition system is also described to collect a large amount of recording data and analyze the recovered data in real time. In collaboration with researchers in bioMEMS and biomedical science, the functionality and robustness of the IMDs and the supporting systems have been demonstrated with in vivo experiments.
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Date Issued
2019-06-20
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Text
Resource Subtype
Dissertation