Stereoselective synthesis of N-aryl proline amides by biotransformation-Ugi-Smiles sequence

Anass Znabet, Sara Blanken, Elwin Janssen, Frans J J de Kanter, Madeleine Helliwell, Nicholas J Turner, Eelco Ruijter, Romano V A Orru

Research output: Contribution to JournalArticleAcademicpeer-review

Abstract

An efficient combination of MAO-N-catalyzed desymmetrization of cyclic meso-amines with Ugi-Smiles multicomponent chemistry produced optically pure N-aryl proline amides. This method represents the first report of a fully asymmetric Ugi-Smiles process.

Original languageEnglish
Pages (from-to)941-944
Number of pages4
JournalOrganic and Biomolecular Chemistry
Volume10
Issue number5
DOIs
Publication statusPublished - 7 Feb 2012

Keywords

  • Amides/chemical synthesis
  • Amines/chemical synthesis
  • Catalysis
  • Cyclization
  • Models, Molecular
  • Proline/chemical synthesis
  • Stereoisomerism

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