Relaxivity Enhancement of Aquated Tris(β-diketonate)gadolinium(III) Chelates by Confinement within Ultrashort Single-walled Carbon Nanotubes

Date
2014
Journal Title
Journal ISSN
Volume Title
Publisher
John Wiley & Sons, Inc.
Description
Abstract

Ultrashort single-walled carbon nanotubes loaded with gadolinium ions (gadonanotubes) have been previously shown to exhibit extremely high T1-weighted relaxivities (>100 mM-1s-1). To further examine the effect of nanoconfinement on the relaxivity of gadolinium based contrast agents for magnetic resonance imaging (MRI), a series of ultrashort single-walled carbon nanotube (US-tube) materials internally loaded with gadolinium chelates has been prepared and studied. US-tubes were loaded with Gd(acac)3ᄋ2H2O, Gd(hfac)3ᄋ2H2O, and Gd(thd)3. (acac = acetylacetone, hfac = hexafluoroacetylacetone, thd = tetramethylheptanedione) The longitudinal relaxivities of the prepared materials determined at 25ᄚC in a 1.5 T field were 103 mM-1s-1 for Gd(acac)3ᄋ2H2O@US-tubes, 105 mM-1s-1 for Gd(hfac)3ᄋ2H2O@US-tubes and 26 mM-1s-1 for Gd(thd)3@US-tubes. Compared to the relaxivities obtained for the unloaded chelates (<10 mM-1s-1) as well as accounting for the T1 reduction observed for the empty US-tubes, the boost in relaxivity for chelate-loaded US-tubes is attributed to confinement within the nanotube and depends on the number of coordinated water molecules.

Description
Advisor
Degree
Type
Journal article
Keywords
Citation

Law, Justin J., Guven, Adem and Wilson, Lon J.. "Relaxivity Enhancement of Aquated Tris(β-diketonate)gadolinium(III) Chelates by Confinement within Ultrashort Single-walled Carbon Nanotubes." Contrast Media & Molecular Imaging, (2014) John Wiley & Sons, Inc.: http://dx.doi.org/10.1002/cmmi.1603.

Has part(s)
Forms part of
Rights
This is an author's peer-reviewed final manuscript, as accepted by the publisher. The published article is copyrighted by Wiley.
Link to license
Citable link to this page