Development of a multimodal foveated endomicroscope for the detection of oral cancer
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A multimodal endomicroscope was developed for cancer detection that combines hyperspectral and confocal imaging through a single foveated objective and a vibrating optical fiber bundle. Standard clinical examination has a limited ability to identify early stage oral cancer. Optical detection methods are typically restricted by either achievable resolution or a small field-of-view. By combining high resolution and widefield spectral imaging into a single probe, a device was developed that provides spectral and spatial information over a 5 mm field to locate suspicious lesions that can then be inspected in high resolution mode. The device was evaluated on ex vivo biopsies of human oral tumors.
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Shadfan, Adam, Darwiche, Hawraa, Blanco, Jesus, et al.. "Development of a multimodal foveated endomicroscope for the detection of oral cancer." Biomedical Optics Express, 8, no. 3 (2017) The Optical Society: 1525-1535. https://doi.org/10.1364/BOE.8.001525.