Variants of the lantibiotic MU1140 and other lantibiotics with improved pharmacological properties and structural features
Abstract
The invention provides improvements of lantibiotics useful for reducing the numbers of microbes or the reproduction of microbes in or on subjects or objects. One embodiment of the invention provides variants of antibiotics wherein the amino acid at position (1) is changed to Ile or Gly, the amino acid at position (4) is changed to an Ala, the amino acid at position (4) is removed, the amino acid at position (5) is changed to an Ala, or wherein, as in the case of MU1140, the amino acid at position (13) is Arg, the Arg at position (13) is substituted with Asp, or combinations of two or more these changes or a pharmaceutically acceptable salt thereof.
Subject
C07K 14/195A01N 25/34
A01N 63/02
A23G 4/123
A23L 2/52
A61K 8/64
A61K 8/99
A61K 35/744
A61K 38/164
A61K 39/09
A61K 45/06
A61Q 11/00
C07K 14/315
C12N 9/0006
A23V 2002/00
A61K 38/12
A61K 39/02
A61K 2800/74
C12Y 101/01001
A61P 1/02
A61P 31/04
A01N 63/10
Y02A 50/30
Y02A 50/473
Collections
Citation
Hillman, Jeffrey D.; Smith, James Leif; Wilson-Stanford, Shawanda R. (2018). Variants of the lantibiotic MU1140 and other lantibiotics with improved pharmacological properties and structural features. United States. Patent and Trademark Office; Texas A&M University. Libraries. Available electronically from https : / /hdl .handle .net /1969 .1 /177246.