Titill: | Randomized Noninferiority Trial of Telephone vs In-Person Genetic Counseling for Hereditary Breast and Ovarian Cancer: A 12-Month Follow-Up |
Höfundur: |
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Útgáfa: | 2017-09-01 |
Tungumál: | Enska |
Háskóli/Stofnun: | Háskólinn í Reykjavík Reykjavik University |
Svið: | Viðskiptadeild (HR) School of Business (RU) |
Birtist í: | JNCI Cancer Spectrum;1(1) |
ISSN: | 2515-5091 (eISSN) |
DOI: | 10.1093/jncics/pkx002 |
Efnisorð: | Female; Breast cancer; Ovarian cancer; Genetic counseling; Telephone counseling; Patient satisfaction; Konur; Brjóstakrabbamein; Eggjastokkar; Krabbamein; Erfðaráðgjöf; Sjúklingafræðsla; Ráðgjöf; Símtöl; Sjúklingar; Ánægja; Sálfræði; Psychology |
URI: | https://hdl.handle.net/20.500.11815/1510 |
Tilvitnun:Interrante, M. K., Segal, H., Peshkin, B. N., Valdimarsdottir, H. B., Nusbaum, R., Similuk, M., DeMarco, T., Hooker, G., Graves, K., Isaacs, C., Wood, M., McKinnon, W., Garber, J., McCormick, S., Heinzmann, J., Kinney, A. Y., & Schwartz, M. D. (2017). Randomized Noninferiority Trial of Telephone vs In-Person Genetic Counseling for Hereditary Breast and Ovarian Cancer: A 12-Month Follow-Up. Jnci Cancer Spectrum, 1(1), UNSP pkx002. https://doi.org/10.1093/jncics/pkx002
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Útdráttur:Background: Telephone delivery of genetic counseling is an alternative to in-person genetic counseling because it may extend the reach of genetic counseling. Previous reports have established the noninferiority of telephone counseling on short-term psychosocial and decision-making outcomes. Here we examine the long-term impact of telephone counseling (TC) vs inperson counseling (usual care [UC]).
Methods: We recruited high-risk women for a noninferiority trial comparing TC with UC. Of 1057 potentially eligible women, 669 were randomly assigned to TC (n = 335) or UC (n = 334), and 512 completed the 12-month follow-up. Primary outcomes were patient-reported satisfaction with genetic testing decision, distress, and quality of life. Secondary outcomes were uptake of cancer risk management strategies.
Results: TC was noninferior to UC on all primary outcomes. Satisfaction with decision (d = 0.13, lower bound of 97.5% confidence interval [CI] = -0.34) did not cross its one-point noninferiority limit, cancer-specific distress (d = -2.10, upper bound of 97.5% CI = -0.07) did not cross its four-point noninferiority limit, and genetic testing distress (d = -0.27, upper bound of 97.5% CI = 1.46), physical function (d = 0.44, lower bound of 97.5% CI = -0.91) and mental function (d = -0.04, lower bound of 97.5% CI = -1.44) did not cross their 2.5-point noninferiority limit. Bivariate analyses showed no differences in risk-reducing mastectomy or oophorectomy across groups; however, when combined, TC had significantly more risk-reducing surgeries than UC (17.8% vs 10.5%; chi(2) = 4.43, P = .04).
Conclusions: Findings support telephone delivery of genetic counseling to extend the accessibility of this service without long-termadverse outcomes.
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Leyfi:© The Author 2017. Published by Oxford University Press.
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/
licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
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