A candidate gene study of capecitabine-related toxicity in colorectal cancer identifies new toxicity variants at DPYD and a putative role for ENOSF1 rather than TYMS.

Rosmarin, Dan; Palles, Claire; Pagnamenta, Alistair; Kaur, Kulvinder; Pita, Guillermo; Martin, Miguel; Domingo, Enric; Jones, Angela; Howarth, Kimberley; Freeman-Mills, Luke; Johnstone, Elaine; Wang, Haitao; Love, Sharon; Scudder, Claire; Julier, Patrick; Fernández-Rozadilla, Ceres; Ruiz-Ponte, Clara; Carracedo, Angel; Castellvi-Bel, Sergi; Castells, Antoni; Gonzalez-Neira, Anna; Taylor, Jenny; Kerr, Rachel; Kerr, David; Tomlinson, Ian

Document types check

Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.12530/23810

Title:	A candidate gene study of capecitabine-related toxicity in colorectal cancer identifies new toxicity variants at DPYD and a putative role for ENOSF1 rather than TYMS.
Authors:	Rosmarin, Dan Palles, Claire Pagnamenta, Alistair Kaur, Kulvinder Pita, Guillermo Martin, Miguel Domingo, Enric Jones, Angela Howarth, Kimberley Freeman-Mills, Luke Johnstone, Elaine Wang, Haitao Love, Sharon Scudder, Claire Julier, Patrick Fernández-Rozadilla, Ceres Ruiz-Ponte, Clara Carracedo, Angel Castellvi-Bel, Sergi Castells, Antoni Gonzalez-Neira, Anna Taylor, Jenny Kerr, Rachel Kerr, David Tomlinson, Ian View more
Keywords:	Cancer Cancer Genetics Chemotherapy Pharmacogenetics View more
Mesh:	Adult Aged Aged, 80 and over Antimetabolites, Antineoplastic Capecitabine Colorectal Neoplasms Deoxycytidine Dihydrouracil Dehydrogenase (NADP) Female Fluorouracil Humans Male Middle Aged Proteins Thymidylate Synthase Young Adult Genetic Association Studies Polymorphism, Genetic View more
Issue Date:	Jan-2015
Citation:	Gut.2015 Jan;(64)1:111-20
Abstract:	Capecitabine is an oral 5-fluorouracil (5-FU) pro-drug commonly used to treat colorectal carcinoma and other tumours. About 35% of patients experience dose-limiting toxicity. The few proven genetic biomarkers of 5-FU toxicity are rare variants and polymorphisms, respectively, at candidate loci dihydropyrimidine dehydrogenase (DPYD) and thymidylate synthase (TYMS).
PMID:	24647007
URI:	https://hdl.handle.net/20.500.12530/23810
Rights:	openAccess
Appears in Collections:	Fundaciones e Institutos de Investigación > IIS H. General U. Gregorio Marañón > Artículos

Files in This Item:

File	Description	Size	Format
PMC4283622.pdf		1.96 MB	Adobe PDF	View/Open

Show full item record