Title: | Identification of four novel susceptibility loci for oestrogen receptor negative breast cancer. |
Authors: | Couch, Fergus JKuchenbaecker, Karoline BMichailidou, KyriakiMendoza-Fandino, Gustavo ANord, SiljeLilyquist, JannaOlswold, CurtisHallberg, EmilyAgata, SimonaAhsan, HabibulAittomäki, KristiinaAmbrosone, ChristineAndrulis, Irene LAnton-Culver, HodaArndt, VolkerArun, Banu KArver, BritaBarile, MonicaBarkardottir, Rosa BBarrowdale, DanielBeckmann, LarsBeckmann, Matthias WBenitez, JavierBlank, Stephanie VBlomqvist, CarlBogdanova, Natalia VBojesen, Stig EBolla, Manjeet KBonanni, BernardoBrauch, HiltrudBrenner, HermannBurwinkel, BarbaraBuys, Saundra SCaldes, TrinidadCaligo, Maria ACanzian, FedericoCarpenter, JaneChang-Claude, JennyChanock, Stephen JChung, Wendy KClaes, Kathleen B MCox, AngelaCross, Simon SCunningham, Julie MCzene, KamilaDaly, Mary BDamiola, FrancescaDarabi, Hatefde la Hoya, MiguelDevilee, PeterDiez, OrlandDing, Yuan CDolcetti, RiccardoDomchek, Susan MDorfling, Cecilia MDos-Santos-Silva, IsabelDumont, MartineDunning, Alison MEccles, Diana MEhrencrona, HansEkici, Arif BEliassen, HeatherEllis, SteveFasching, Peter AFigueroa, JonineFlesch-Janys, DieterFörsti, AstaFostira, FlorentiaFoulkes, William DFriebel, TaraFriedman, EitanFrost, DebraGabrielson, MarikeGammon, Marilie DGanz, Patricia AGapstur, Susan MGarber, JudyGaudet, Mia MGayther, Simon AGerdes, Anne-MarieGhoussaini, MayaGiles, Graham GGlendon, GordGodwin, Andrew KGoldberg, Mark SGoldgar, David EGonzález-Neira, AnnaGreene, Mark HGronwald, JacekGuénel, PascalGunter, MarcHaeberle, LotharHaiman, Christopher AHamann, UteHansen, Thomas V OHart, StevenHealey, SueHeikkinen, TuomasHenderson, Brian EHerzog, JosefHogervorst, Frans B LHollestelle, AntoinetteHooning, Maartje JHoover, Robert NHopper, John LHumphreys, KeithHunter, David JHuzarski, TomaszImyanitov, Evgeny NIsaacs, ClaudineJakubowska, AnnaJames, PaulJanavicius, RamunasJensen, Uffe BirkJohn, Esther MJones, MichaelKabisch, MariaKar, SiddharthaKarlan, Beth YKhan, SofiaKhaw, Kay-TeeKibriya, Muhammad GKnight, Julia AKo, Yon-DschunKonstantopoulou, IreneKosma, Veli-MattiKristensen, VesselaKwong, AvaLaitman, YaelLambrechts, DietherLazaro, ConxiLee, EunjungLe Marchand, LoicLester, JennyLindblom, AnnikaLindor, NoralaneLindstrom, SaraLiu, JianjunLong, JirongLubinski, JanMai, Phuong LMakalic, EnesMalone, Kathleen EMannermaa, ArtoManoukian, SiranoushMargolin, SaraMarme, FrederikMartens, John W MMcGuffog, LesleyMeindl, AlfonsMiller, AustinMilne, Roger LMiron, PenelopeMontagna, MarcoMazoyer, SylvieMulligan, Anna MMuranen, Taru ANathanson, Katherine LNeuhausen, Susan LNevanlinna, HeliNordestgaard, Børge GNussbaum, Robert LOffit, KennethOlah, EdithOlopade, Olufunmilayo IOlson, Janet EOsorio, AnaPark, Sue KPeeters, Petra HPeissel, BernardPeterlongo, PaoloPeto, JulianPhelan, Catherine MPilarski, RobertPoppe, BrucePylkäs, KatriRadice, PaoloRahman, NazneenRantala, JohannaRappaport, ChristineRennert, GadRichardson, AndreaRobson, MarkRomieu, IsabelleRudolph, AnjaRutgers, Emiel JSanchez, Maria-JoseSantella, Regina MSawyer, Elinor JSchmidt, Daniel FSchmidt, Marjanka KSchmutzler, Rita KSchumacher, FredrickScott, RodneySenter, LeighaSharma, PriyankaSimard, JacquesSinger, Christian FSinilnikova, Olga MSoucy, PennySouthey, MelissaSteinemann, DorisStenmark-Askmalm, MarieStoppa-Lyonnet, DominiqueSwerdlow, AnthonySzabo, Csilla ITamimi, RullaTapper, WilliamTeixeira, Manuel RTeo, Soo-HwangTerry, Mary BThomassen, MadsThompson, DeborahTihomirova, LaimaToland, Amanda ETollenaar, Robert A E MTomlinson, IanTruong, ThérèseTsimiklis, HelenTeulé, AlexTumino, RosarioTung, NadineTurnbull, ClareUrsin, Giskivan Deurzen, Carolien H Mvan Rensburg, Elizabeth JVaron-Mateeva, RaymondaWang, ZhaomingWang-Gohrke, ShanWeiderpass, ElisabeteWeitzel, Jeffrey NWhittemore, AliceWildiers, HansWinqvist, RobertYang, Xiaohong RYannoukakos, DrakoulisYao, SongZamora, M PilarZheng, WeiHall, PerKraft, PeterVachon, CelineSlager, SusanChenevix-Trench, GeorgiaPharoah, Paul D PMonteiro, Alvaro A NGarcía-Closas, MontserratEaston, Douglas FAntoniou, Antonis C |
Mesh: | |
Issue Date: | 2016 |
Citation: | Nat Commun.2016 04;(7):11375 |
Abstract: | Common variants in 94 loci have been associated with breast cancer including 15 loci with genome-wide significant associations (P<5 × 10(-8)) with oestrogen receptor (ER)-negative breast cancer and BRCA1-associated breast cancer risk. In this study, to identify new ER-negative susceptibility loci, we performed a meta-analysis of 11 genome-wide association studies (GWAS) consisting of 4,939 ER-negative cases and 14,352 controls, combined with 7,333 ER-negative cases and 42,468 controls and 15,252 BRCA1 mutation carriers genotyped on the iCOGS array. We identify four previously unidentified loci including two loci at 13q22 near KLF5, a 2p23.2 locus near WDR43 and a 2q33 locus near PPIL3 that display genome-wide significant associations with ER-negative breast cancer. In addition, 19 known breast cancer risk loci have genome-wide significant associations and 40 had moderate associations (P<0.05) with ER-negative disease. Using functional and eQTL studies we implicate TRMT61B and WDR43 at 2p23.2 and PPIL3 at 2q33 in ER-negative breast cancer aetiology. All ER-negative loci combined account for ∼11% of familial relative risk for ER-negative disease and may contribute to improved ER-negative and BRCA1 breast cancer risk prediction. |
PMID: | 27117709 |
URI: | https://hdl.handle.net/20.500.12530/26734 |
Rights: | openAccess |
Appears in Collections: | Fundaciones e Institutos de Investigación > IIS H. U. La Paz > Artículos Fundaciones e Institutos de Investigación > IIS H. U. Clínico San Carlos > Artículos Hospitales > H. U. La Paz > Artículos
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