Oral myeloid cells uptake allergoids coupled to mannan driving Th1/Treg responses upon sublingual delivery in mice.

Document types check

Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.12530/38199

Title:	Oral myeloid cells uptake allergoids coupled to mannan driving Th1/Treg responses upon sublingual delivery in mice.
Authors:	Soria, I López-Relaño, J Viñuela, M Tudela, J-I Angelina, A Benito-Villalvilla, C Díez-Rivero, C M Cases, B Manzano, A I Fernández-Caldas, E Casanovas, M Palomares, O Subiza, J L View more
Keywords:	allergoid glycoconjugate immunotherapy mannan sublingual View more
Mesh:	Animals Antigen-Presenting Cells Female Mannans Mice Mice, Inbred BALB C Mouth Mucosa Myeloid Cells Plant Extracts Sublingual Immunotherapy T-Lymphocytes, Regulatory Th1 Cells Administration, Sublingual View more
Issue Date:	2018
Citation:	Allergy.2018 04;(73)4:875-884
Abstract:	Polymerized allergoids coupled to nonoxidized mannan (PM-allergoids) may represent novel vaccines targeting dendritic cells (DCs). PM-allergoids are better captured by DCs than native allergens and favor Th1/Treg cell responses upon subcutaneous injection. Herein we have studied in mice the in vivo immunogenicity of PM-allergoids administered sublingually in comparison with native allergens.
PMID:	29319882
URI:	https://hdl.handle.net/20.500.12530/38199
Rights:	openAccess
Appears in Collections:	Fundaciones e Institutos de Investigación > IIS H. U. Clínico San Carlos > Artículos

Files in This Item:

File	Description	Size	Format
PMC5947296.pdf		1.06 MB	Adobe PDF	View/Open