Variation at FCGR2A and functionally related genes is associated with the response to anti-TNF therapy in rheumatoid arthritis.

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Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.12530/40414

Title:	Variation at FCGR2A and functionally related genes is associated with the response to anti-TNF therapy in rheumatoid arthritis.
Authors:	Avila-Pedretti, Gabriela Tornero, Jesús Fernández-Nebro, Antonio Blanco, Francisco González-Alvaro, Isidoro Cañete, Juan D Maymó, Joan Alperiz, Mercedes Fernández-Gutiérrez, Benjamín Olivé, Alex Corominas, Héctor Erra, Alba Aterido, Adrià López Lasanta, María Tortosa, Raül Julià, Antonio Marsal, Sara View more
Mesh:	Adult Antirheumatic Agents Arthritis, Rheumatoid Female Humans Macrophages Male Receptors, IgG Synovial Fluid Treatment Outcome Tumor Necrosis Factor-alpha Polymorphism, Single Nucleotide View more
Issue Date:	2015
Citation:	PLoS ONE.2015;(10)4:e0122088
Abstract:	Anti-TNF therapies have been highly efficacious in the management of rheumatoid arthritis (RA), but 25-30% of patients do not show a significant clinical response. There is increasing evidence that genetic variation at the Fc receptor FCGR2A is associated with the response to anti-TNF therapy. We aimed to validate this genetic association in a patient cohort from the Spanish population, and also to identify new genes functionally related to FCGR2A that are also associated with anti-TNF response.
PMID:	25848939
URI:	https://hdl.handle.net/20.500.12530/40414
Rights:	openAccess
Appears in Collections:	Fundaciones e Institutos de Investigación > IIS H. U. La Princesa > Artículos Fundaciones e Institutos de Investigación > IIS H. U. Clínico San Carlos > Artículos

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