Please use this identifier to cite or link to this item:
https://hdl.handle.net/20.500.12530/40842
Title: | Whole-exome sequencing identifies rare pathogenic variants in new predisposition genes for familial colorectal cancer. | |
Authors: | ||
Mesh: | ||
Issue Date: | Feb-2015 | |
Citation: | Genet. Med..2015 Feb;(17)2:131-42 | |
Abstract: | Colorectal cancer is an important cause of mortality in the developed world. Hereditary forms are due to germ-line mutations in APC, MUTYH, and the mismatch repair genes, but many cases present familial aggregation but an unknown inherited cause. The hypothesis of rare high-penetrance mutations in new genes is a likely explanation for the underlying predisposition in some of these familial cases. | |
PMID: | 25058500 | |
URI: | https://hdl.handle.net/20.500.12530/40842 | |
Rights: | openAccess | |
Appears in Collections: | Fundaciones e Institutos de Investigación > IIS H. U. Clínico San Carlos > Artículos | |
Files in This Item:
File | Description | Size | Format | |
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PMC4318970.pdf | 1.03 MB | Adobe PDF | View/Open |
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