Agradecimentos: We acknowledge the support of the National Institute of Health (NIH) through grants R01-NS060653 (AY), P41-EB015893 (AY and JD), and 1R01NS082309-01A1 (WK, RB, WB, and AY), as well as the support by the Sao Paulo Research Foundation (FAPESP) through grants 2013/07559-3 (RM) and...

Agradecimentos: We acknowledge the support of the National Institute of Health (NIH) through grants R01-NS060653 (AY), P41-EB015893 (AY and JD), and 1R01NS082309-01A1 (WK, RB, WB, and AY), as well as the support by the Sao Paulo Research Foundation (FAPESP) through grants 2013/07559-3 (RM) and 2016/13139-5 (RF). We would also like to acknowledge the research coordinator responsible for this project, Nichole Galatti

Abstract: Introduction: Mechanical thrombectomy is revolutionizing treatment of acute stroke due to large vessel occlusion (LVO). Unfortunately, use of the modified Thrombolysis in Cerebral Infarction score (mTICI) to characterize recanalization of the cerebral vasculature does not address...

Abstract: Introduction: Mechanical thrombectomy is revolutionizing treatment of acute stroke due to large vessel occlusion (LVO). Unfortunately, use of the modified Thrombolysis in Cerebral Infarction score (mTICI) to characterize recanalization of the cerebral vasculature does not address microvascular perfusion of the distal parenchyma, nor provide more than a vascular "snapshot." Thus, little is known about tissue-level hemodynamic consequences of LVO recanalization. Diffuse correlation spectroscopy (DCS) and diffuse optical spectroscopy (DOS) are promising methods for continuous, noninvasive, contrast-free transcranial monitoring of cerebral microvasculature. Methods: Here, we use a combined DCS/DOS system to monitor frontal lobe hemodynamic changes during endovascular treatment of 2 patients with ischemic stroke due to internal carotid artery (ICA) occlusions. Results and Discussion: The monitoring instrument identified a recanalization-induced increase in ipsilateral cerebral blood flow (CBF) with little or no concurrent change in contralateral CBF and extracerebral blood flow. The results suggest that diffuse optical monitoring is sensitive to intracerebral hemodynamics in patients with ICA occlusion and can measure microvascular responses to mechanical thrombectomy

FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO - FAPESP

2013/07559-3; 2016/13139-5

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