Agradecimentos: Echodia (St Beauzire, France) for providing audiological diagnostic equipment and technical support. NUPAD/UFMG for supporting research through the Program of Control of Congenital Toxoplasmosis in Minas Gerais. This study was financed in part by the Coordenação de Aperfeiçoamento de...

Agradecimentos: Echodia (St Beauzire, France) for providing audiological diagnostic equipment and technical support. NUPAD/UFMG for supporting research through the Program of Control of Congenital Toxoplasmosis in Minas Gerais. This study was financed in part by the Coordenação de Aperfeiçoamento de Pesquisas de Nível Superior – Brasil (Capes), FINEP and CNPq. The Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) supported this work through 309144/2018-3 and 430455/2018-6. The São Paulo Research Foundation (FAPESP) supported this work through 2016/22990-0, 2013/07559-3, and 2019/21962-1

Abstract: Congenital toxoplasmosis (CT) is a known cause of hearing loss directly caused by Toxoplasma gondii. Hearing loss might result from sensory, neural, or sensorineural lesions. Early treated infants rarely develop hearing loss, but retinochoroidal lesions, intracranial calcifications and...

Abstract: Congenital toxoplasmosis (CT) is a known cause of hearing loss directly caused by Toxoplasma gondii. Hearing loss might result from sensory, neural, or sensorineural lesions. Early treated infants rarely develop hearing loss, but retinochoroidal lesions, intracranial calcifications and hydrocephalus are common. In this study, we aimed to evaluate the brain evoked hemodynamic responses of CT and healthy infants during four auditory stimuli: mother infant directed speech, researcher infant directed speech, mother reading and researcher recorded. Children underwent Transitionally Evoked Otoacoustic Emission Auditory Testing and Automated Brainstem Auditory Response tests with normal auditory results, but with a tendency for greater latencies in the CT group compared to the control group. We assessed brain hemodynamics with functional near-infrared spectroscopy (fNIRS) measurements from 61 infants, and we present fNIRS results as frequency maps of activation and deactivation for each stimulus. By evaluating infants in the three first months of life, we observed an individual heterogeneous brain activation pattern in response to all auditory stimuli for both groups. Each channel was activated or deactivated in less than 30% of children for all stimuli. There is a need of prospective studies to evaluate if the neurologic or auditory changes course with compromise of children outcomes

COORDENAÇÃO DE APERFEIÇOAMENTO DE PESSOAL DE NÍVEL SUPERIOR - CAPES

FINANCIADORA DE ESTUDOS E PROJETOS - FINEP

CONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO - CNPQ

309144/2018-3; 430455/2018-6

FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO - FAPESP

2013/07559-3; 2016/22990-0; 2019/21962-1

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